Over the course of the series, the time-travelling hero will revisit his old enemy The Ood - a race of squid-like humans - and drop in on famous crime novellist Agatha Christie.
"Visiting Agatha Christie has been on my wish-list for ages now, and for the Doctor, it's a real meeting of minds," said executive producer and lead writer Russell T Davies.
Agatha Christie's grandson, Mathew Prichard, said it was a "brilliant idea" to introduce her to the show.
"As far as I know my grandmother never saw Doctor Who, but I am sure she would have been intrigued, excited and above all flattered by all this attention in 2007," he said.
Christie's role will be played by actress Fenella Woolgar, who was recently seen in BBC One's Jekyll.
Fenella Woolgar has also appeared in Agatha Christie's 'Lord Edgware Dies'.